[HTML][HTML] Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks

SN Wright, BS Leger, SB Rosenthal, SN Liu, T Jia… - Cell reports, 2023 - cell.com
A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

The genetic architecture of behavioral canalization

RRH Anholt, TFC Mackay - Trends in Genetics, 2023 - cell.com
Behaviors are components of fitness and contribute to adaptive evolution. Behaviors
represent the interactions of an organism with its environment, yet innate behaviors display …

[HTML][HTML] A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

TV de Jong, Y Pan, P Rastas, D Munro, M Tutaj, H Akil… - Cell Genomics, 2024 - cell.com
The seventh iteration of the reference genome assembly for Rattus norvegicus—mRatBN7.
2—corrects numerous misplaced segments and reduces base-level errors by approximately …

[HTML][HTML] Social fear extinction susceptibility is associated with Microbiota-Gut-Brain axis alterations

NL Ritz, TFS Bastiaanssen, CSM Cowan… - Brain, Behavior, and …, 2024 - Elsevier
Social anxiety disorder is a common psychiatric condition that severely affects individual
quality of life and is a significant societal burden. Although many risk factors for social …

Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure

VA Wagner, KL Holl, KC Clark, JJ Reho… - Toxicological …, 2023 - academic.oup.com
Environmental bisphenol compounds like bisphenol F (BPF) are endocrine-disrupting
chemicals (EDCs) affecting adipose and classical endocrine systems. Genetic factors that …

A Cost-effective, High-throughput, Highly Accurate Genotyping Method for Outbred Populations

D Chen, AS Chitre, KMH Nguyen… - G3: Genes …, 2024 - academic.oup.com
Affordable sequencing and genotyping methods are essential for large scale genome-wide
association studies. While genotyping microarrays and reference panels for imputation are …

[HTML][HTML] GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

YZ Jiang, LY Hu, MS Chen, XJ Wang… - World Journal of Stem …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Thrombocytopenia 2, an autosomal dominant inherited disease
characterized by moderate thrombocytopenia, predisposition to myeloid malignancies and …

Genome‐wide association study of delay discounting in Heterogeneous Stock rats

MK Lara, AS Chitre, D Chen… - Genes, Brain and …, 2024 - Wiley Online Library
Delay discounting refers to the behavioral tendency to devalue rewards as a function of their
delay in receipt. Heightened delay discounting has been associated with substance use …

[HTML][HTML] Inbred rat heredity and sex affect oral oxycodone self-administration and augmented intake in long sessions: correlations with anxiety and novelty-seeking

BM Sharp, S Leng, J Huang, C Jones, H Chen - bioRxiv, 2023 - ncbi.nlm.nih.gov
Oxycodone abuse begins with prescription oral oxycodone, yet vulnerability factors
determining abuse are largely undefined. We evaluated genetic vulnerability in a rat model …

Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats

BN Kuhn, N Cannella, AS Chitre, KMH Nguyen… - bioRxiv, 2024 - biorxiv.org
The increased prevalence of opioid use disorder (OUD) makes it imperative to disentangle
the biological mechanisms contributing to individual differences in OUD vulnerability. OUD …