• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

version of the Guidelines, which is freely available via the ESC and EAS websites and
hosted on their journals' websites (EHJ and Atherosclerosis Journal). The National Cardiac …

BackgroundPeripheral low-grade inflammation in depression is increasingly seen as a
therapeutic target. We aimed to establish the prevalence of low-grade inflammation in …

Albumin, the most abundant circulating protein in blood, is an essential protein which binds
and transports various drugs and substances, maintains the oncotic pressure of blood and …

C-reactive protein (CRP) is routinely assessed as a marker of systemic inflammation in
rheumatoid arthritis (RA). However, it is also an immune regulator that plays an important …

Obesity is the accumulation of abnormal or excessive fat that may interfere with the
maintenance of an optimal state of health. The excess of macronutrients in the adipose …

Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are
small (104 amino acids) and have a striking relationship to the acute phase response with …

Recent findings have deeply changed the current view of coronary heart disease, going
beyond the simplistic model of atherosclerosis as a passive process involving cholesterol …

Inflammatory reactivity to acute laboratory stress is thought to reflect individual differences in
responsivity to environmental stressors and may confer future health risk. To characterize …

Short sleep duration has a substantial influence on the overall health of an individual. Short
sleep time can be a consequence of lifestyle habits, environmental factors, or the presence …