Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
Proliferation control in neural stem and progenitor cells
CCF Homem, M Repic, JA Knoblich - Nature Reviews Neuroscience, 2015 - nature.com
Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …
produced during development or by a reduction in adult cell number owing to disease. For …
Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families
AM Alazami, N Patel, HE Shamseldin, S Anazi… - Cell reports, 2015 - cell.com
Our knowledge of disease genes in neurological disorders is incomplete. With the aim of
closing this gap, we performed whole-exome sequencing on 143 multiplex consanguineous …
closing this gap, we performed whole-exome sequencing on 143 multiplex consanguineous …
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading
frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal …
frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal …
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
Primary microcephaly is caused by mutations in genes encoding centrosomal proteins
including WDR62 and KIF2A. However, mechanisms underlying human microcephaly …
including WDR62 and KIF2A. However, mechanisms underlying human microcephaly …
Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage
Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic …
been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic …
Two dimensional ice from first principles: Structures and phase transitions
Despite relevance to disparate areas such as cloud microphysics and tribology, major gaps
in the understanding of the structures and phase transitions of low-dimensional water ice …
in the understanding of the structures and phase transitions of low-dimensional water ice …
Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management
D Devakumar, A Bamford, MU Ferreira… - The Lancet infectious …, 2018 - thelancet.com
Microcephaly is an important sign of neurological malformation and a predictor of future
disability. The 2015–16 outbreak of Zika virus and congenital Zika infection brought the …
disability. The 2015–16 outbreak of Zika virus and congenital Zika infection brought the …
Prolonged mitosis of neural progenitors alters cell fate in the developing brain
Embryonic neocortical development depends on balanced production of progenitors and
neurons. Genetic mutations disrupting progenitor mitosis frequently impair neurogenesis; …
neurons. Genetic mutations disrupting progenitor mitosis frequently impair neurogenesis; …
Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy
CA Martin, I Ahmad, A Klingseisen, MS Hussain… - Nature …, 2014 - nature.com
Centrioles are essential for ciliogenesis. However, mutations in centriole biogenesis genes
have been reported in primary microcephaly and Seckel syndrome, disorders without the …
have been reported in primary microcephaly and Seckel syndrome, disorders without the …