Mycotoxin: Its impact on gut health and microbiota

WPP Liew, S Mohd-Redzwan - Frontiers in cellular and infection …, 2018 - frontiersin.org
The secondary metabolites produced by fungi known as mycotoxins, are capable of causing
mycotoxicosis (diseases and death) in human and animals. Contamination of feedstuffs as …

Toxicity of mycotoxins in vivo on vertebrate organisms: A review

A Cimbalo, M Alonso-Garrido, G Font… - Food and Chemical …, 2020 - Elsevier
Mycotoxins are considered to be a major risk factor affecting human and animal health as
they are one of the most dangerous contaminants of food and feed. This review aims to …

Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice

S Liu, W Kang, X Mao, L Ge, H Du, J Li… - Journal of pineal …, 2022 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is a widespread contaminant in foods and feedstuffs, and its
target organ is the liver. Melatonin (MT) has been shown to alleviate inflammation in organs …

Aflatoxin detoxification using microorganisms and enzymes

Y Guan, J Chen, E Nepovimova, M Long, W Wu… - Toxins, 2021 - mdpi.com
Mycotoxin contamination causes significant economic loss to food and feed industries and
seriously threatens human health. Aflatoxins (AFs) are one of the most harmful mycotoxins …

Impact of mycotoxins on the intestine: are mucus and microbiota new targets?

H Robert, D Payros, P Pinton, V Theodorou… - Journal of Toxicology …, 2017 - Taylor & Francis
There is an increasing awareness of the deleterious effects attributed to mycotoxins during
their fate within the gut, particularly for deoxynivalenol (DON), zearalenone (ZEN) …

The compromised intestinal barrier induced by mycotoxins

Y Gao, L Meng, H Liu, J Wang, N Zheng - Toxins, 2020 - mdpi.com
Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially
threatening human and animal health. The intestine is considered as the first barrier against …

Aflatoxin B1 Induces Inflammatory Liver Injury via Gut Microbiota in Mice

L Ye, H Chen, KWK Tsim, X Shen, X Li… - Journal of Agricultural …, 2023 - ACS Publications
Aflatoxin B1 (AFB1), a potent food-borne hepatocarcinogen, is the most toxic aflatoxin that
induces liver injury in humans and animals. Species-specific sensitivities of aflatoxins …

Effects of melatonin on liver injuries and diseases

JJ Zhang, X Meng, Y Li, Y Zhou, DP Xu, S Li… - International Journal of …, 2017 - mdpi.com
Liver injuries and diseases are serious health problems worldwide. Various factors, such as
chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a …

Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in …

LY Zhang, DL Zhan, YY Chen, WH Wang, CY He… - Archives of …, 2019 - Springer
Abstract Aflatoxin B1 (AFB1), a food contaminant derived from Aspergillus fungi, has been
reported to cause hepatic immunotoxicity via inflammatory infiltration and cytokines release …

Aflatoxin B1 induces intestinal barrier dysfunction by regulating the FXR-mediated MLCK signaling pathway in mice and in IPEC-J2 cells

S Liu, J Li, W Kang, Y Li, L Ge, D Liu… - Journal of agricultural …, 2022 - ACS Publications
Aflatoxin B1 (AFB1) is a widespread mycotoxin in food and feed. Although the liver is the
main target organ of AFB1, the intestine is the first exposure organ to AFB1. However, the …