Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …

Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and
non-cell autonomous processes, leading to several consequences for the organism. To …

The African turquoise killifish has recently gained significant traction as a new research
organism in the aging field. Our understanding of aging has strongly benefited from …

Age-related changes to histone levels are seen in many species. However, it is unclear
whether changes to histone expression could be exploited to ameliorate the effects of …

The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a
genome protective barrier and mechanotransduction interface between the cytoplasm and …

Objective Oxidative stress (OS) has been previously linked to the aging process, as have
some diseases and geriatric syndromes as frailty and sarcopenia. The aim of the present …

Abstract Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr)
enzyme involved in multiple cellular pathways implicated in aging and metabolism …

Here we review the examples of great longevity and potential immortality in the earliest
animal types and contrast and compare these to humans and other higher animals. We start …