The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein
kinase that integrates inputs from nutrients and growth factors to control many fundamental …

Background The identification in murine bone marrow (BM) of CD133+/Lin-/CD45-cells,
possessing several features of pluripotent stem cells, encouraged us to investigate if similar …

Background Endometrial carcinoma (EC) is one of the most common gynecological
malignancies among women. Maternal embryonic leucine Zipper Kinase (MELK) is …

Rutin is one of the flavonoids found in fruits and vegetables. Recent reports have revealed
that rutin is a major player in proliferation and bone development. However, data on how …

Rationale: Wear particle-induced periprosthetic osteolysis (PPO) is a common long-term
complication of total joint arthroplasty, and represents the major cause of aseptic loosening …

Intervertebral disc (IVD) degeneration is the major contributor to low back pain, a highly
prevalent musculoskeletal problem that represents the leading cause of disability …

Osteoblasts, the chief bone‐forming cells, are differentiated from mesenchymal stromal/stem
cells. Disruption of this differentiation process can cause osteoporosis, a bone disease …

Osteoporosis, a systemic bone disease defined by decreased bone mass and deterioration
of bone microarchitecture, is becoming a global concern. Nodakenin (NK) is a …

Skeletal stem/progenitor cells (SSPCs) can differentiate into osteogenic or adipogenic
lineage. The mechanism governing lineage allocation of SSPCs is still not completely …

Abstract Background/Objective Histology-based analyses are important tools to dissect
cellular and molecular mechanisms of skeletal homeostasis, diseases, and regeneration …