Highly multiplexed spatial profiling with CODEX: bioinformatic analysis and application in human disease

W Kuswanto, G Nolan, G Lu - Seminars in Immunopathology, 2023 - Springer
Multiplexed imaging, which enables spatial localization of proteins and RNA to cells within
tissues, complements existing multi-omic technologies and has deepened our …

Insights into the tumor microenvironment of B cell lymphoma

WL Ng, SM Ansell, P Mondello - Journal of Experimental & Clinical Cancer …, 2022 - Springer
The standard therapies in lymphoma have predominantly focused on targeting tumor cells
with less of a focus on the tumor microenvironment (TME), which plays a critical role in …

Follicular lymphoma: The long and winding road leading to your cure?

MJ Gordon, MR Smith, LJ Nastoupil - Blood Reviews, 2023 - Elsevier
Follicular lymphoma, the most common indolent lymphoma, though highly responsive to
therapy is coupled with multiple relapses for the majority of patients. Advances in biologic …

PARP14 is a novel target in STAT6 mutant follicular lymphoma

M Mentz, W Keay, CD Strobl, M Antoniolli, L Adolph… - Leukemia, 2022 - nature.com
The variable clinical course of follicular lymphoma (FL) is determined by the molecular
heterogeneity of tumor cells and complex interactions within the tumor microenvironment …

Mapping cancer biology in space: applications and perspectives on spatial omics for oncology

S Lee, G Kim, JY Lee, AC Lee, S Kwon - Molecular Cancer, 2024 - Springer
Technologies to decipher cellular biology, such as bulk sequencing technologies and single-
cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent …

T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma

ZZ Yang, HJ Kim, H Wu, X Tang, Y Yu, J Krull… - Blood cancer …, 2023 - nature.com
T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL).
However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets …

Minimal residual disease detection in lymphoma: methods, procedures and clinical significance

S Zhang, X Wang, Z Yang, M Ding, M Zhang… - Frontiers in …, 2024 - frontiersin.org
Lymphoma is a highly heterogeneous lymphohematopoietic tumor. As our understanding of
the biological and pathological characteristics of lymphoma improves, we are identifying an …

Cell cross talk within the lymphoma tumor microenvironment: follicular lymphoma as a paradigm

C Laurent, S Dietrich, K Tarte - Blood, 2024 - ashpublications.org
Follicular lymphoma (FL) is an indolent yet incurable germinal center B-cell lymphoma
retaining a characteristic follicular architecture. FL tumor B cells are highly dependent on …

Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma

RA Lacinski, SA Dziadowicz, VK Melemai… - Bone Research, 2024 - nature.com
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have
abysmal five-year overall survival rates. The complexity of the osteosarcoma immune tumor …

Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients

C Li, N Guo, S Han, H Yu, T Lei, X Chen… - Cancer …, 2024 - Wiley Online Library
Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma
(FL) remain controversial. Methods Immunohistochemistry was used to examine expression …