The adult skeleton is renewed by remodeling throughout life. Bone remodeling is a process
where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit …

The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone
resorption were first described in the late 1960s. In the 50 years that have elapsed since …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for
bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone …

All factors influencing the material composition and structure of bone do so through the final
common cellular pathways of modeling and remodeling. During growth, modeling, the …

Context There are few studies on patients transitioning from denosumab to
bisphosphonates. Objective To investigate patient characteristics and changes in bone …

The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Vertebral fractures and trabecular bone loss are hallmarks of osteoporosis. However, 80% of
fractures are non-vertebral and 70% of all bone loss is cortical and is produced by …

Bisphosphonates (BPs) are bone-avid compounds used as first-line medications for the
prevention and treatment of osteoporosis. They are also used in other skeletal pathologies …