The safety of progestogens as a class has come under increased scrutiny after the
publication of data from the Women's Health Initiative trial, particularly with respect to breast …

This review discusses mechanisms by which progesterone receptors (PR) regulate
transcription. We examine available data in different species and tissues regarding:(1) …

Synthetic progestins are used by millions of women as contraceptives and in hormone
replacement therapy (HRT), although their molecular mechanisms of action are not well …

Access to effective affordable contraception is critical for individual and public health. A wide
range of hormonal contraceptives (HCs), which differ in composition, concentration of the …

Background In four randomized, controlled, European trials, dienogest 2 mg once daily
demonstrated significant efficacy for lesion reduction and reduction in pain intensity in …

Progesterone is indispensable for differentiation of human endometrial stromal cells
(HESCs) into decidual cells, a process that critically controls embryo implantation. We now …

Steroid receptors (SRs) are members of the nuclear receptor family, which are ligand-
activated transcription factors. SRs regulate many physiological functions including …

The ovarian hormones progesterone and estrogen play important roles in breast cancer
etiology, proliferation, and treatment. Androgens may also contribute to breast cancer risk …

Breast cancer occurs at a high frequency in women and, given this fact, a primary focus of
breast cancer research has been the study of estrogen receptor α (ER) signaling. However …

Medroxyprogesterone acetate (MPA) has been in clinical use for over 30 years, and was
generally considered to be safe until the results of long-term studies of postmenopausal …