[HTML][HTML] Illuminating RNA biology through imaging

P Le, N Ahmed, GW Yeo - Nature cell biology, 2022 - nature.com
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …

Targeted RNA editing: novel tools to study post-transcriptional regulation

W Xu, J Biswas, RH Singer, M Rosbash - Molecular cell, 2022 - cell.com
RNA binding proteins (RBPs) regulate nearly all post-transcriptional processes within cells.
To fully understand RBP function, it is essential to identify their in vivo targets. Standard …

[HTML][HTML] Modular, programmable RNA sensing using ADAR editing in living cells

KE Kaseniit, N Katz, NS Kolber, CC Call… - Nature …, 2023 - nature.com
With the increasing availability of single-cell transcriptomes, RNA signatures offer a
promising basis for targeting living cells. Molecular RNA sensors would enable the study of …

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

S Benbarche, JMB Pineda, LB Galvis, J Biswas, B Liu… - Molecular Cell, 2024 - cell.com
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid
cancers and result in widespread alterations in splicing, yet there is currently no therapeutic …

Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells

KC Abruzzi, C Ratner, M Rosbash - Rna, 2023 - rnajournal.cshlp.org
RNA binding proteins (RBPs) perform a myriad of functions and are implicated in numerous
neurological diseases. To identify the targets of RBPs in small numbers of cells, we …

[HTML][HTML] Profiling dynamic RNA–protein interactions using small-molecule-induced RNA editing

KW Seo, RE Kleiner - Nature chemical biology, 2023 - nature.com
RNA-binding proteins (RBPs) play an important role in biology, and characterizing dynamic
RNA–protein interactions is essential for understanding RBP function. In this study, we …

Genome-wide profiling of rice Double-stranded RNA-Binding Protein 1–associated RNAs by targeted RNA editing

S Yin, Y Chen, Y Chen, L Xiong, K Xie - Plant Physiology, 2023 - academic.oup.com
RNA-binding proteins (RBPs) play essential roles in regulating gene expression. However,
the RNA ligands of RBPs are poorly understood in plants, not least due to the lack of efficient …

A transient in planta editing assay identifies specific binding of the splicing regulator PTB as a prerequisite for cassette exon inclusion

J Loeser, J Bauer, K Janßen, K Rockenbach… - Plant Molecular …, 2024 - Springer
The dynamic interaction of RNA-binding proteins (RBPs) with their target RNAs contributes
to the diversity of ribonucleoprotein (RNP) complexes that are involved in a myriad of …

The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth

RA Alizzi, D Xu, CM Tenenbaum, W Wang… - PLoS genetics, 2020 - journals.plos.org
Dendritic arbor morphology influences how neurons receive and integrate extracellular
signals. We show that the ELAV/Hu family RNA-binding protein Found in neurons (Fne) is …

Zipcode binding protein 1 (ZBP1; IGF2BP1): a model for sequence-specific RNA regulation

J Biswas, L Nunez, S Das, YJ Yoon… - Cold Spring Harbor …, 2019 - symposium.cshlp.org
The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by
interactions with RNA binding proteins (RBPs). β-actin mRNA has functioned as the classic …