Emerging compounds and therapeutic strategies to treat infections from Trypanosoma brucei: an overhaul of the last 5-years patents

F Melfi, S Carradori, C Campestre… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Human African Trypanosomiasis is a neglected disease caused by
infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are …

Advancement in the development of DNA vaccines against Trypanosoma brucei and future perspective

MT Aleem, F Munir, A Shakoor, F Gao - International …, 2024 - Elsevier
Trypanosomes are the extracellular protozoan parasites that cause human African
trypanosomiasis disease in humans and nagana disease in animals. Tsetse flies act as a …

[HTML][HTML] Designing a candidate multi-epitope vaccine against transmissible gastroenteritis virus based on immunoinformatic and molecular dynamics

Y Bai, M Zhou, N Wang, Y Yang, D Wang - International Journal of …, 2024 - mdpi.com
Transmissible gastroenteritis virus (TGEV) is an etiological agent of enteric disease that
results in high mortality rates in piglets. The economic impact of the virus is considerable …

[HTML][HTML] Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis

AU Danazumi, IT Ishmam, S Idris, MA Izert… - European Journal of …, 2023 - Elsevier
African trypanosomiasis (AT) is a hemoparasitic disease caused by infection with African
trypanosomes and it is prevalent in many sub-Saharan African countries, affecting both …

Molecular and Immunological Properties of a Chimeric Glycosyl Hydrolase 18 Based on Immunoinformatics Approaches: A Design of a New Anti-Leishmania Vaccine

JE da Cruz Freire, AN Cardeal dos Santos… - ACS Pharmacology & …, 2024 - ACS Publications
Leishmaniasis is a chronic inflammatory zoonotic illness caused by protozoan flagellates
belonging to the Leishmania genus. Current data suggest that over 1 billion people …

[HTML][HTML] A novel approach to design chimeric multi epitope vaccine against Leishmania exploiting infected host cell proteome

S Banesh, N Gupta, CV Reddy, U Mallikarjunachari… - Heliyon, 2024 - cell.com
Leishmaniasis is a major infectious disease having high mortality which could be attributed
to lack of a suitable vaccine candidate. We propose a novel approach to design multiepitope …

Current vaccines, experimental immunization trials, and new perspectives to control selected vector borne blood parasites of veterinary importance

HF Alzan, MS Mahmoud, CE Suarez - Frontiers in Veterinary Science, 2024 - frontiersin.org
Parasite infections transmitted by vectors such as ticks and blood-sucking arthropods pose a
significant threat to both human and animal health worldwide and have a substantial …

[HTML][HTML] Computational Workflow to Design Novel Vaccine Candidates and Small-Molecule Therapeutics for Schistosomiasis

EO Balogun, GI Joseph, SC Olabode, NA Dayaso… - Pathogens, 2024 - mdpi.com
Human schistosomiasis, caused by the Schistosoma trematode, is a neglected parasitic
disease affecting over 250 million people worldwide. There is no vaccine, and the single …

[HTML][HTML] A Universal Multi-Epitope Vaccine Design Against Porcine Reproductive and Respiratory Syndrome Virus via Bioinformatics and Immunoinformatics …

X Lei, Z Wu, Q Feng, W Jia, J Xie, Q Zhou, J Ban… - Veterinary …, 2024 - mdpi.com
Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive
disorders in sows and severe pneumonia in piglets, alongside immunosuppressive effects …

Whole proteome screening to develop a potent epitope-based vaccine against Coxiella burnetii: a reverse vaccinology approach

A Forouharmehr - Journal of Biomolecular Structure and Dynamics, 2024 - Taylor & Francis
Coxiellosis is known as a threat to human health. This study aimed to develop an epitope-
based vaccine against coxiellosis using a whole proteome investigation. In this case, the …