Understanding the scientific validity of synthetic torpor for radiation research and extended space missions

AP Kokko, R Chowdhury, K Sherman… - Frontiers in Space …, 2024 - frontiersin.org
The idea of synthetic torpor, an artificial state resembling the hypo-metabolic state of
torpor/hibernation, has recently gained significant scientific attention. Building on pioneering …

Effects of non‐rapid eye movement sleep on the cortical synaptic expression of GluA1‐containing AMPA receptors

F Squarcio, G Tononi, C Cirelli - European Journal of …, 2024 - Wiley Online Library
Converging electrophysiological, molecular and ultrastructural evidence supports the
hypothesis that sleep promotes a net decrease in excitatory synaptic strength, counteracting …

Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain

T Hitrec, F Squarcio, E Piscitiello, M Cerri… - Journal of Comparative …, 2024 - Springer
Abstract Neuronal Tau protein hyperphosphorylation (PPtau) is a hallmark of tauopathic
neurodegeneration. However, a reversible brain PPtau occurs in mammals during either …

Effects of NREM sleep on cortical synapses

F Squarcio, G Tononi, C Cirelli - 2024 - advance.sagepub.com
Converging electrophysiological, molecular, and ultrastructural evidence supports the
hypothesis that sleep promotes a net decrease in excitatory synaptic strength, counteracting …