Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+
recycling in organs including the heart, brain, and gut. Loss of function is relatively common …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

The cardiac KCNQ1 potassium channel carries the important IKs current and controls the
heart rhythm. Hundreds of mutations in KCNQ1 can cause life-threatening cardiac …

Superresolution imaging methods—now widely used to characterize biological structures
below the diffraction limit—are poised to reveal in quantitative detail the stoichiometry of …

In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes
sequential activation from the resting state to the intermediate state and activated state to …

The delayed rectifier potassium IKs channel is an important regulator of the duration of the
ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) …

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7. 1 and the β-subunit
KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study …

Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …