Advanced tandem mass spectrometry in metabolomics and lipidomics—methods and applications
S Heiles - Analytical and Bioanalytical Chemistry, 2021 - Springer
Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
Deep-lipidotyping by mass spectrometry: recent technical advances and applications
In-depth structural characterization of lipids is an essential component of lipidomics. There
has been a rapid expansion of mass spectrometry methods that are capable of resolving …
has been a rapid expansion of mass spectrometry methods that are capable of resolving …
Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome
Fatty acid isomers are responsible for an under-reported lipidome diversity across all
kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary …
kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary …
High-throughput plasma lipidomics: detailed mapping of the associations with cardiometabolic risk factors
High-throughput targeted lipid profiling with liquid chromatography-mass spectrometry (LC-
MS) has been used extensively to identify associations between plasma lipid species and …
MS) has been used extensively to identify associations between plasma lipid species and …
Large-scale lipid analysis with C=C location and sn-position isomer resolving power
Lipids play a pivotal role in biological processes and lipid analysis by mass spectrometry
(MS) has significantly advanced lipidomic studies. While the structure specificity of lipid …
(MS) has significantly advanced lipidomic studies. While the structure specificity of lipid …
Pinpointing Double Bond and sn-Positions in Glycerophospholipids via Hybrid 193 nm Ultraviolet Photodissociation (UVPD) Mass Spectrometry
Complete structural characterization of complex lipids, such as glycerophospholipids, by
tandem mass spectrometry (MS/MS) continues to present a major challenge. Conventional …
tandem mass spectrometry (MS/MS) continues to present a major challenge. Conventional …
Mass spectrometry imaging with isomeric resolution enabled by ozone‐induced dissociation
Mass spectrometry imaging (MSI) enables the spatial distributions of molecules possessing
different mass‐to‐charge ratios to be mapped within complex environments revealing …
different mass‐to‐charge ratios to be mapped within complex environments revealing …
Identification of Double Bond Position Isomers in Unsaturated Lipids by m-CPBA Epoxidation and Mass Spectrometry Fragmentation
Lipids are highly diverse biomolecules associated with several biological functions including
structural constituent, energy storage, and signal transduction. It is essential to characterize …
structural constituent, energy storage, and signal transduction. It is essential to characterize …
Apocryphal FADS2 activity promotes fatty acid diversification in cancer
Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result
in products with well-defined chain lengths, degree (s), and positions of unsaturation. Deep …
in products with well-defined chain lengths, degree (s), and positions of unsaturation. Deep …
Mass spectrometry imaging of lipids with isomer resolution using high-pressure ozone-induced dissociation
Mass spectrometry imaging (MSI) of lipids within tissues has significant potential for both
biomolecular discovery and histopathological applications. Conventional MSI technologies …
biomolecular discovery and histopathological applications. Conventional MSI technologies …