Protein kinase C: perfectly balanced
AC Newton - Critical reviews in biochemistry and molecular …, 2018 - Taylor & Francis
Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …
evolved unique features distinguishing them from all other protein kinases. The atypical …
The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases
Kinases form the backbone of numerous cell signaling pathways, with their dysfunction
similarly implicated in multiple pathologies. Further facilitated by their druggability, kinases …
similarly implicated in multiple pathologies. Further facilitated by their druggability, kinases …
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
TR Baffi, G Lordén, JM Wozniak, A Feichtner… - Science …, 2021 - science.org
The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …
New perspectives, opportunities, and challenges in exploring the human protein kinome
LJ Wilson, A Linley, DE Hammond, FE Hood… - Cancer research, 2018 - AACR
The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity
Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …
potentially damaging roles in human diseases. In this study, we found that the catalytic …
Reversing the paradigm: protein kinase C as a tumor suppressor
AC Newton, J Brognard - Trends in pharmacological sciences, 2017 - cell.com
The discovery in the 1980s that protein kinase C (PKC) is a receptor for the tumor-promoting
phorbol esters fueled the dogma that PKC is an oncoprotein. Yet 30+ years of clinical trials …
phorbol esters fueled the dogma that PKC is an oncoprotein. Yet 30+ years of clinical trials …
Protein kinase C as a tumor suppressor
AC Newton - Seminars in cancer biology, 2018 - Elsevier
Protein kinase C (PKC) has historically been considered an oncoprotein. This stems in large
part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting …
part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting …
Tracing the origin and evolution of pseudokinases across the tree of life
Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
Pseudokinases: update on their functions and evaluation as new drug targets
The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …
60 signaling proteins, which lacks one or more of the amino acids typically required to …