Pathophysiological mechanisms implicated in postpartum depression

JL Payne, J Maguire - Frontiers in neuroendocrinology, 2019 - Elsevier
This review aims to summarize the diverse proposed pathophysiological mechanisms
contributing to postpartum depression, highlighting both clinical and basic science research …

The neurobiology of postpartum anxiety and depression

JL Pawluski, JS Lonstein, AS Fleming - Trends in neurosciences, 2017 - cell.com
Ten to twenty percent of postpartum women experience anxiety or depressive disorders,
which can have detrimental effects on the mother, child, and family. Little is known about the …

Is postpartum depression different from depression occurring outside of the perinatal period? A review of the evidence

MM Batt, KA Duffy, AM Novick, CA Metcalf… - Focus, 2020 - Am Psychiatric Assoc
Whether a major depressive episode occurring in the postpartum period (ie, postpartum
depression [PPD]) is sufficiently distinct from major depressive episodes occurring at other …

Characterizing the brain structural adaptations across the motherhood transition

M Martínez-García, M Paternina-Die… - Frontiers in Global …, 2021 - frontiersin.org
Women that become mothers face notable physiological adaptations during this life-period.
Neuroimaging studies of the last decade have provided grounded evidence that women's …

Maternal childhood trauma, postpartum depression, and infant outcomes: Avoidant affective processing as a potential mechanism

KW Choi, KJ Sikkema, B Vythilingum, L Geerts… - Journal of affective …, 2017 - Elsevier
Background Women who have experienced childhood trauma may be at risk for postpartum
depression, increasing the likelihood of negative outcomes among their children. Predictive …

Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders

AP Borrow, NM Cameron - Progress in Neuro-Psychopharmacology and …, 2014 - Elsevier
Clinical research has demonstrated a significant sex difference in the occurrence of
depressive disorders. Beginning at pubertal onset, women report a higher incidence of …

GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study

KM Deligiannidis, EM Sikoglu, SA Shaffer… - Journal of psychiatric …, 2013 - Elsevier
Postpartum depression (PPD) affects up to 1 in 8 women. The early postpartum period is
characterized by a downward physiological shift from relatively elevated levels of sex …

Postpartum depression and brain response to infants: Differential amygdala response and connectivity

KE Wonch, CB de Medeiros, JA Barrett… - Social …, 2016 - Taylor & Francis
Recent evidence suggests that postpartum depression is associated with reduced amygdala
(AMY) response to negative stimuli. However, given the anhedonic features of PPD, it is …

Neural correlates of depression in women across the reproductive lifespan–An fMRI review

S Stickel, L Wagels, O Wudarczyk, S Jaffee… - Journal of affective …, 2019 - Elsevier
Introduction Depressive disorders in women emerge largely during transitions in their
reproductive aging cycle, which can be attributed to internal endocrine possesses that affect …

Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle in rats

SR Blume, M Padival, JH Urban, JA Rosenkranz - Scientific Reports, 2019 - nature.com
Stress is a precipitating factor in depression and anxiety disorders. Patients with these
disorders often show amygdala abnormalities. The basolateral amygdala (BLA) is integral in …