Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …

Recent discoveries in stem cell and developmental biology have introduced a new era
marked by the generation of in vitro models that recapitulate early mammalian development …

Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

Embryonic development is a highly intricate and complex process. Different regulatory
mechanisms cooperatively dictate the fate of cells as they progress from pluripotent stem …

While studied extensively in model systems, human gastrulation remains obscure. The
scarcity of fetal biological material as well as ethical considerations limit our understanding …

‘Ceci n’est pas un embryon?’ The ethics of human embryo model research | Nature Methods
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

How cells build embryos is still a major mystery. Many unresolved questions require the
study of the processes that pattern and shape the embryo in live specimens, in toto, across …

Objective To present the ethical issues, moral arguments, and reasons found in the ethical
literature on organoid models. Design In this systematic review of reasons in ethical …