During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM),
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …

The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

Suicide is one of the leading causes of death globally for all ages, and as such presents a
very serious problem for clinicians worldwide. However, the underlying neurobiological …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Abstract The Nexilin F‐Actin Binding Protein (Nexilin) encoded by NEXN is a cardiac Z‐disc
protein important for cardiac function and development in humans, zebrafish, and mice …

Hereditary cardiomyopathies (CMPs), including arrhythmogenic cardiomyopathy (ACM),
dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy (HCM), represent a group …

Dilated cardiomyopathy (DCM) is a life-threatening form of heart disease that is typically
characterized by progressive thinning of the ventricular walls, chamber dilation, and systolic …

Sarcoplasmic reticulum (SR) is a specialized tubular network, which not only maintains the
intracellular concentration of Ca2+ at a low level but is also known to release and …