The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed
PEGylation, is a well‐established and clinically proven drug delivery approach to improve …

Though we crossed many milestones in the field of medicine and health care in eradicating
some deadly diseases over the past decades, cancer remained a challenge taking the lives …

Since the licensing of the first monoclonal antibody therapy in 1986, monoclonal antibodies
have become the largest class of biopharmaceuticals with over 80 antibodies currently …

The focus of nanoparticle design over the years has evolved toward more complex
nanoscopic core–shell architecture using a single delivery system to combine multiple …

Curcumin (CCM) is one of the most frequently explored plant compounds with various
biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and …

The safety and efficacy of protein therapeutics are limited by three interrelated
pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives …

Introduction: Missing abstinence outcomes are a universal challenge for tobacco cessation
studies. The biases inherent in the complete case analysis, where cases missing outcomes …

Therapeutics must diffuse through the brain extracellular space (ECS) in order to distribute
within the central nervous system (CNS) compartment; this requirement holds both for drugs …

Background Subcutaneous pegylated interferon (peginterferon) beta-1a is being developed
for treatment of relapsing multiple sclerosis, with less frequent dosing than currently …

This study addresses the cellular uptake and intracellular trafficking of 15‐nm gold
nanoparticles (NPs), either plain (ie, stabilized with citrate) or coated with polyethylene …