Nicotine is the principal addictive component that drives continued tobacco use despite
users' knowledge of the harmful consequences. The initiation of addiction involves the …

A major hurdle in defining the molecular biology of nicotine addiction has been
characterizing the different nicotinic acetylcholine receptor (nAChR) subtypes in the brain …

Rationale: Nicotine dependence has been associated with impulsivity and discounting
delayed/uncertain outcomes. Objectives: This study had two main objectives:(1) to examine …

Abuse of psychoactive substances can lead to drug addiction. In animals, addiction is best
modeled by drug self-administration paradigms. It has been proposed that the crucial …

Understanding effects of chronic nicotine requires identifying the neurons and synapses
whose responses to nicotine itself, and to endogenous acetylcholine, are altered by …

Parkinson's disease is a debilitating movement disorder characterized by a generalized
dysfunction of the nervous system, with a particularly prominent decline in the nigrostriatal …

The addiction‐relevant molecular, cellular, and behavioral actions of nicotine are derived
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …

This review summarizes studies that attempted to determine the subtypes of nicotinic
acetylcholine receptors (nAChR) expressed in the dopaminergic nerve terminals in the …

Tobacco smoking is highly addictive and causes respiratory disease, cardiovascular
disease and multiple types of cancer. Electronic‐cigarettes (e‐cigarettes) are non …

Diseases associated with tobacco use constitute a major health problem worldwide. Upon
cessation of tobacco use, an unpleasant withdrawal syndrome occurs in dependent …