MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

Background Celastrol, a triterpene compound derived from the traditional Chinese medicine
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …

Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …

Reprograming the N 6-methyladenosine (m6A) landscape is a promising therapeutic
strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) …

For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and
glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular …

Transcription factors have roles at focal points in signaling pathways, controlling many
normal cellular processes, such as cell growth and proliferation, metabolism, apoptosis …

Despite advances in our understanding of the molecular basis for particular subtypes of
acute myeloid leukemia (AML), effective therapy remains a challenge for many individuals …

Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional
coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and …

Targeting of general coactivators is an emerging strategy to interfere with oncogenic
transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects …