Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …

The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …

Besides its role in homologous recombination, the tumor suppressor BRCA2 protects stalled
replication forks from nucleolytic degradation. Defective fork stability contributes to …

Both embryonic and adult stem cells are endowed with a superior capacity to prevent the
accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Human cleavage-stage embryos frequently acquire chromosomal aneuploidies during
mitosis due to unknown mechanisms. Here, we show that S phase at the 1-cell stage shows …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

Flaws in the DNA replication process have emerged as a leading driver of genome
instability in human diseases. Alteration to replication fork progression is a defining feature …

Glioblastoma (GBM) is a lethal primary brain tumor characterized by treatment resistance
and inevitable tumor recurrence, both of which are driven by a subpopulation of GBM cancer …