Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury

S Lehnardt - Glia, 2010 - Wiley Online Library
Microglia are key players of the immune response in the central nervous system (CNS) and,
being the resident innate immune cells, they are responsible for the early control of …

Herpes simplex virus type 1 infection of the central nervous system: insights into proposed interrelationships with neurodegenerative disorders

LF Duarte, MA Farías, DM Álvarez… - Frontiers in Cellular …, 2019 - frontiersin.org
Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain
without evident clinical symptoms. Once in the central nervous system (CNS), the virus can …

Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease

SA Harris, EA Harris - Journal of Alzheimer's Disease, 2015 - content.iospress.com
This review focuses on research in epidemiology, neuropathology, molecular biology, and
genetics regarding the hypothesis that pathogens interact with susceptibility genes and are …

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

MA Wozniak, AP Mee, RF Itzhaki - The Journal of Pathology: A …, 2009 - Wiley Online Library
The brains of Alzheimer's disease sufferers are characterized by amyloid plaques and
neurofibrillary tangles. However, the cause (s) of these features and those of the disease are …

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

FG Lafaille, IM Pessach, SY Zhang, MJ Ciancanelli… - Nature, 2012 - nature.com
In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn
errors of toll-like receptor 3 (TLR3) immunity are prone to HSV-1 encephalitis (HSE),,. We …

[HTML][HTML] Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

KM Park, WJ Bowers - Cellular signalling, 2010 - Elsevier
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory molecule, which upon
engagement with its cognate receptors on target cells, triggers downstream signaling …

The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity–a tale of conflict and conundrum

M Müller, S Carter, MJ Hofer… - Neuropathology and …, 2010 - Wiley Online Library
M. Müller, S. Carter, MJ Hofer and IL Campbell (2010) Neuropathology and Applied
Neurobiology36, 368–387 The chemokine receptor CXCR3 and its ligands CXCL9 …

Molecular mechanisms for herpes simplex virus type 1 pathogenesis in Alzheimer's disease

SA Harris, EA Harris - Frontiers in aging neuroscience, 2018 - frontiersin.org
This review focuses on research in the areas of epidemiology, neuropathology, molecular
biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative …

TNF-Mediated Homeostatic Synaptic Plasticity: From in vitro to in vivo Models

R Heir, D Stellwagen - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Since it was first described almost 30 years ago, homeostatic synaptic plasticity (HSP) has
been hypothesized to play a key role in maintaining neuronal circuit function in both …