Membrane-interacting antifungal peptides

C Struyfs, BPA Cammue, K Thevissen - Frontiers in cell and …, 2021 - frontiersin.org
The incidence of invasive fungal infections is increasing worldwide, resulting in more than
1.6 million deaths every year. Due to growing antifungal drug resistance and the limited …

[HTML][HTML] Two small, cysteine-rich and cationic antifungal proteins from Penicillium chrysogenum: A comparative study of PAF and PAFB

A Huber, L Galgóczy, G Váradi, J Holzknecht… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The filamentous fungus Penicillium chrysogenum Q176 secretes the antimicrobial proteins
(AMPs) PAF and PAFB, which share a compact disulfide-bond mediated, β-fold structure …

The combination of Neosartorya (Aspergillus) fischeri antifungal proteins with rationally designed γ-core peptide derivatives is effective for plant and crop protection

L Tóth, P Poór, A Ördög, G Váradi, A Farkas, C Papp… - BioControl, 2022 - Springer
Plant pathogenic fungi are responsible for enormous crop losses worldwide. Overcoming
this problem is challenging as these fungi can be highly resistant to approved chemical …

The Penicillium chrysogenum Q176 Antimicrobial Protein PAFC Effectively Inhibits the Growth of the Opportunistic Human Pathogen Candida albicans

J Holzknecht, A Kühbacher, C Papp, A Farkas… - Journal of Fungi, 2020 - mdpi.com
Small, cysteine-rich and cationic antimicrobial proteins (AMPs) from filamentous
ascomycetes promise treatment alternatives to licensed antifungal drugs. In this study, we …

[HTML][HTML] Rationally designed antifungal protein chimeras reveal new insights into structure-activity relationship

M Giner-Llorca, FG del Sol, JF Marcos, A Marina… - International journal of …, 2023 - Elsevier
Antifungal proteins (AFPs) are promising antimicrobial compounds that represent a feasible
alternative to fungicides. Penicillium expansum encodes three phylogenetically distinct …

Biofungicidal Potential of Neosartorya (Aspergillus) Fischeri Antifungal Protein NFAP and Novel Synthetic γ-Core Peptides

L Tóth, G Váradi, É Boros, A Borics, H Ficze… - Frontiers in …, 2020 - frontiersin.org
Because of enormous crop losses worldwide due to pesticide-resistant plant pathogenic
fungi, there is an increasing demand for the development of novel antifungal strategies in …

The Epichloë festucae Antifungal Protein Efe-AfpA Protects Creeping Bentgrass (Agrostis stolonifera) from the Plant Pathogen Clarireedia jacksonii, the Causal …

PA Fardella, Z Tian, BB Clarke, FC Belanger - Journal of Fungi, 2022 - mdpi.com
Dollar spot disease, caused by the fungal pathogen Clarireedia jacksonii, is a major
problem in many turfgrass species, particularly creeping bentgrass (Agrostis stolonifera). It is …

At least three families of hyphosphere small secreted cysteine‐rich proteins can optimize surface properties to a moderately hydrophilic state suitable for fungal …

Z Zhao, F Cai, R Gao, M Ding, S Jiang… - Environmental …, 2021 - Wiley Online Library
The secretomes of filamentous fungi contain a diversity of small secreted cysteine‐rich
proteins (SSCPs) that have a variety of properties ranging from toxicity to surface activity …

Navigating the fungal battlefield: cysteine-rich antifungal proteins and peptides from Eurotiales

J Holzknecht, F Marx - Frontiers in Fungal Biology, 2024 - frontiersin.org
Fungi are ubiquitous in the environment and play a key role in the decomposition and
recycling of nutrients. On the one hand, their special properties are a great asset for the …

Hard nut to crack: Solving the disulfide linkage pattern of the Neosartorya (Aspergillus) fischeri antifungal protein 2

G Váradi, Z Kele, A Czajlik, A Borics, G Bende… - Protein …, 2023 - Wiley Online Library
As a consequence of the fast resistance spreading, a limited number of drugs are available
to treat fungal infections. Therefore, there is an urgent need to develop new antifungal …