The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

The current global obesity pandemic is the leading cause for the soaring rates of metabolic
diseases, especially diabetes, cardiovascular disease, hypertension, and non-alcoholic …

For many years, adipose tissue was considered as an inert energy storage organ that
accumulates and stores triacylglycerols during energy excess and releases fatty acids in …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health.
Circulating adiponectin increases in lean states such as caloric restriction (CR), but the …

White adipose tissue (WAT) is a dynamic and modifiable tissue that develops late during
gestation in humans and through early postnatal development in rodents. WAT is unique in …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …