Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …

Retroviral DNA integration into the host cell genome is an essential feature of the retroviral
life cycle. The ability to integrate their DNA into the DNA of infected cells also makes …

Acetylation of lysine residues, one of the most common protein post‐transcriptional
modifications, is thought to regulate protein affinity with other proteins or nucleotides …

Telomeres form specialized chromatin that protects natural chromosome termini from being
recognized as DNA double-strand breaks. Plants possess unusual blunt-ended telomeres …

There are extensive interactions between viruses and the host DNA damage response
(DDR) machinery. The outcome of these interactions includes not only direct effects on viral …

Ku, a cellular complex required for human cell survival and involved in double strand break
DNA repair and multiple other cellular processes, may modulate retroviral multiplication …

Human Ku heterodimeric protein composed of Ku70 and Ku80 subunits plays an important
role in the non-homologous end-joining DNA repair pathway as a sensor of double strand …

Abstract The HTLV-I oncoprotein Tax interferes with DNA double strand break repair. Since
non-homologous end joining (NHEJ) is a major pathway used to repair DNA double strand …

Human immunodeficiency virus type 1 (HIV-1) is among the best-studied viruses, but some
aspects of HIV-1 biology remain obscure. The role of cell proteins in virus replication raises …

Gene transfer for research or gene therapy requires the design of vectors that allow for
adequate and safe transgene expression. Current methods to modulate the safety and …