The role of bile acids in carcinogenesis

T Režen, D Rozman, T Kovács, P Kovács… - Cellular and molecular …, 2022 - Springer
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

[HTML][HTML] Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

P Sen, S Qadri, PK Luukkonen, O Ragnarsdottir… - Journal of …, 2022 - Elsevier
Background & aims Recent experimental models and epidemiological studies suggest that
specific environmental contaminants (ECs) contribute to the initiation and pathology of non …

Bile acids in glucose metabolism and insulin signalling—mechanisms and research needs

TR Ahmad, RA Haeusler - Nature Reviews Endocrinology, 2019 - nature.com
Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

W Jia, Y Li, KCP Cheung, X Zheng - Science China Life Sciences, 2024 - Springer
Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …

Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes

S Lamichhane, P Sen, AM Dickens, MA Alves… - Cell Reports …, 2022 - cell.com
The gut microbiota is crucial in the regulation of bile acid (BA) metabolism. However, not
much is known about the regulation of BAs during progression to type 1 diabetes (T1D) …

Nanotechnology-assisted liquid crystals-based biosensors: Towards fundamental to advanced applications

J Prakash, A Parveen, YK Mishra, A Kaushik - Biosensors and …, 2020 - Elsevier
Since the discovery of biosensor, continuous efforts are being made to design and develop
novel biosensing systems of reduced form factor and high performance. State-of-art …

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

T Hyötyläinen, L Jerby, EM Petäjä, I Mattila… - Nature …, 2016 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver
disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in …

Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria

K Wegner, S Just, L Gau, H Mueller, P Gérard… - Analytical and …, 2017 - Springer
Bile acids are important signaling molecules that regulate cholesterol, glucose, and energy
homoeostasis and have thus been implicated in the development of metabolic disorders …

Bile acid detection techniques and bile acid-related diseases

X Zhao, Z Liu, F Sun, L Yao, G Yang… - Frontiers in Physiology, 2022 - frontiersin.org
Bile acid is a derivative of cholinergic acid (steroidal parent nucleus) that plays an important
role in digestion, absorption, and metabolism. In recent years, bile acids have been …