In prostate cancer, androgen receptor (AR) binding and androgen-responsive gene
expression are defined by hormone-independent binding patterns of the pioneer factors …

Multicellular tumour spheroids capture many characteristics of human tumour
microenvironments, including hypoxia, and represent an experimentally tractable in vitro …

RNAi, post-transcriptional gene silencing mechanism, could be considered as one of the
most important breakthroughs and rapidly growing fields in science. Researchers are trying …

CRISPR/Cas9-based genome editing offers the possibility to knock out almost any gene of
interest in an affordable and simple manner. The most common strategy is the introduction of …

The enzyme-catalyzed phosphorylation of glucose to glucose-6-phosphate is a reaction
central to the metabolism of all life. ADP-dependent glucokinase (ADPGK) catalyzes glucose …

Hypoxia, a ubiquitous feature of tumors, can be exploited by hypoxia-activated prodrugs
(HAP) that are substrates for one-electron reduction in the absence of oxygen. NADPH …

In higher eukaryotes, several ATP-utilizing enzymes known as hexokinases activate glucose
in the glycolysis pathway by phosphorylation to glucose 6-phosphate. In contrast to …

Glaucomatous neurodegeneration represents one of the major causes of irreversible
blindness worldwide. Yet, the detailed molecular mechanisms that initiate optic nerve …

Hypoxia-activated prodrugs (HAPs) selectively target hypoxic cells associated with
resistance of tumours to radiotherapy/chemotherapy. Although HAPs potentiate …

Prostate cancer remains one of the leading causes of cancer-related deaths in American
men. Further understanding of prostate carcinogenesis therefore remains a top priority in the …