Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Introduction: The failure of many molecules as CNS bioactive compounds is due to many
restrictions: poor water solubility, intestinal absorption, in vivo stability, bioavailability …

Achieving advances in the development of clean and efficient synthetic routes has become
an important aim in research. In recent years, the search for new sustainable methodologies …

Memantine (3, 5-dimethyladamantan-1-amine) is an orally active, noncompetitive N-methyl-
D-aspartate receptor (NMDAR) antagonist approved for treatment of moderate-to-severe …

Introduction: Brain is supposed to be the most complicated part of the body which is very far
from the reach of drug moieties. The drug entry in to the brain region depends upon various …

Background: Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the
elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up …

The molecular pathways contributing to visual signal transduction in the retina generate a
high energy demand that has functional and structural consequences such as …

Solid lipid nanoparticles (SLNs) are considered very attractive drug-delivery systems (DDS)
able to enhance the efficacy of some therapeutic agents in several pathologies difficult to …

Objective The increasing prevalence of antibiotic-resistant bacterial infections led to identify
alternative strategies for a novel therapeutic approach. In this study, we synthesized ten …