Riboswitches are highly conserved RNA elements that located in the 5′-UTR of mRNAs,
which undergo real-time structure conformational change to achieve the regulation of …

The effects of ligand binding on biomolecular conformation are crucial in drug design,
enzyme mechanisms, the regulation of gene expression, and other biological processes …

Investigations of most riboswitches remain confined to the ligand-binding aptamer domain.
However, during the riboswitch mediated transcription regulation process, the aptamer …

Mg2+ is well known to facilitate the structural folding of RNA. However, the thermodynamic
and dynamic roles of Mg2+ in RNA folding remain elusive. Here, we exploit single-molecule …

SAM-I riboswitches regulate gene expression through transcription termination upon binding
a S-adenosyl-L-methionine (SAM) ligand. In previous work, we characterized the …

Single-molecule Förster resonance energy transfer microspectroscopic methods are
employed for real-time monitoring and to gain deeper insights into the formation of the …

The realization that noncoding RNA is implicated in numerous cellular processes, makes it
imperative to understand and predict RNA‐folding. RNA secondary structure prediction is …

Single-molecule measurements are now almost routinely used to study biological systems
and processes. The scope of this special topic emphasizes the physics side of single …

Die vorliegende Dissertation mit dem Titel “Structural dynamics of eukaryotic H/ACA RNPs
from Saccharomyces cerevisiae & Structural dynamics of the Guanidine-II riboswitch from …

Riboswitches are regulatory elements present in bacterial messenger RNA acting as
sensors of small molecules and consequently playing a vital role in bacterial gene …