Ih from synapses to networks: HCN channel functions and modulation in neurons

CL Combe, S Gasparini - Progress in biophysics and molecular biology, 2021 - Elsevier
Hyperpolarization-activated cyclic nucleotide gated (HCN) channels and the current they
carry, I h, are widely and diversely distributed in the central nervous system (CNS). The …

Chemical modulation of Kv7 potassium channels

M Borgini, P Mondal, R Liu, P Wipf - RSC medicinal chemistry, 2021 - pubs.rsc.org
The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …

[HTML][HTML] Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels

E Dossi, L Zonca, H Pivonkova, G Milior, J Moulard… - Cell Reports, 2024 - cell.com
Throughout the brain, astrocytes form networks mediated by gap junction channels that
promote the activity of neuronal ensembles. Although their inputs on neuronal information …

The ionic mechanism of membrane potential oscillations and membrane resonance in striatal LTS interneurons

SC Song, JA Beatty, CJ Wilson - Journal of …, 2016 - journals.physiology.org
Striatal low-threshold spiking (LTS) interneurons spontaneously transition to a depolarized,
oscillating state similar to that seen after sodium channels are blocked. In the depolarized …

[HTML][HTML] Recurrence-based synchronization analysis of weakly coupled bursting neurons under external ELF fields

AM Nkomidio, EK Ngamga, BRN Nbendjo, J Kurths… - Entropy, 2022 - mdpi.com
We investigate the response characteristics of a two-dimensional neuron model exposed to
an externally applied extremely low frequency (ELF) sinusoidal electric field and the …

[HTML][HTML] Post-stroke epileptogenesis is associated with altered intrinsic properties of hippocampal pyramidal neurons leading to increased theta resonance

J Vera, K Lippmann - Neurobiology of Disease, 2021 - Elsevier
Brain insults like stroke, trauma or infections often lead to blood-brain barrier-dysfunction
(BBBd) frequently resulting into epileptogenesis. Affected patients suffer from seizures and …

[HTML][HTML] Intracellular properties of deep-layer pyramidal neurons in frontal eye field of macaque monkeys

C Piette, M Vandecasteele, C Bosch-Bouju… - Frontiers in Synaptic …, 2021 - frontiersin.org
Although many details remain unknown, several positive statements can be made about the
laminar distribution of primate frontal eye field (FEF) neurons with different physiological …

[HTML][HTML] Mixed-mode oscillations in pyramidal neurons under antiepileptic drug conditions

B V-Ghaffari, M Kouhnavard, SM Elbasiouny - PloS one, 2017 - journals.plos.org
Subthreshold oscillations in combination with large-amplitude oscillations generate mixed-
mode oscillations (MMOs), which mediate various spatial and temporal cognition and …

[HTML][HTML] Electrical resonance with voltage-gated ion channels: perspectives from biophysical mechanisms and neural electrophysiology

L Ge, X Liu - Acta Pharmacologica Sinica, 2016 - nature.com
Electrical resonance, providing selective signal amplification at preferred frequencies, is a
unique phenomenon of excitable membranes, which has been observed in the nervous …

Kv11 (ether‐à‐go‐go‐related gene) voltage‐dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials

T Matsuoka, M Yamasaki, M Abe… - The Journal of …, 2021 - Wiley Online Library
Key points Some ion channels are known to behave as inductors and make up the parallel
resonant circuit in the plasma membrane of neurons, which enables neurons to respond to …