Three faces of biofilms: a microbial lifestyle, a nascent multicellular organism, and an incubator for diversity

A Penesyan, IT Paulsen, S Kjelleberg… - npj Biofilms and …, 2021 - nature.com
Biofilms are organised heterogeneous assemblages of microbial cells that are encased
within a self-produced matrix. Current estimates suggest that up to 80% of bacterial and …

Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal

D McDougald, SA Rice, N Barraud… - Nature Reviews …, 2012 - nature.com
In most environments, bacteria reside primarily in biofilms, which are social consortia of cells
that are embedded in an extracellular matrix and undergo developmental programmes …

Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses

JB Kaplan - Journal of dental research, 2010 - journals.sagepub.com
Like all sessile organisms, surface-attached communities of bacteria known as biofilms must
release and disperse cells into the environment to colonize new sites. For many pathogenic …

Physiological heterogeneity in biofilms

PS Stewart, MJ Franklin - Nature Reviews Microbiology, 2008 - nature.com
Biofilms contain bacterial cells that are in a wide range of physiological states. Within a
biofilm population, cells with diverse genotypes and phenotypes that express distinct …

The developmental model of microbial biofilms: ten years of a paradigm up for review

RD Monds, GA O'Toole - Trends in microbiology, 2009 - cell.com
For the past ten years, the developmental model of microbial biofilm formation has served as
the major conceptual framework for biofilm research; however, the paradigmatic value of this …

Rapid microevolution of biofilm cells in response to antibiotics

A Penesyan, SS Nagy, S Kjelleberg… - NPJ biofilms and …, 2019 - nature.com
Infections caused by Acinetobacter baumannii are increasingly antibiotic resistant,
generating a significant public health problem. Like many bacteria, A. baumannii adopts a …

Heterogeneity in Pseudomonas aeruginosa biofilms includes expression of ribosome hibernation factors in the antibiotic-tolerant subpopulation and hypoxia-induced …

KS Williamson, LA Richards… - Journal of …, 2012 - Am Soc Microbiol
Bacteria growing in biofilms are physiologically heterogeneous, due in part to their
adaptation to local environmental conditions. Here, we characterized the local transcriptome …

The biofilm life cycle and virulence of Pseudomonas aeruginosa are dependent on a filamentous prophage

SA Rice, CH Tan, PJ Mikkelsen, V Kung, J Woo… - The ISME …, 2009 - academic.oup.com
Mature Pseudomonas aeruginosa biofilms undergo specific developmental events. Using a
bacteriophage mutant, generated by deletion of the entire filamentous Pf4 prophage, we …

Antibiotic delivery strategies to treat skin infections when innate antimicrobial defense fails

R Smith, J Russo, J Fiegel, N Brogden - Antibiotics, 2020 - mdpi.com
The epidermal skin barrier protects the body from a host of daily challenges, providing
protection against mechanical insults and the absorption of chemicals and xenobiotics. In …

Experimental evolution in biofilm populations

HP Steenackers, I Parijs, KR Foster… - FEMS microbiology …, 2016 - academic.oup.com
Biofilms are a major form of microbial life in which cells form dense surface associated
communities that can persist for many generations. The long-life of biofilm communities …