Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation …
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and
remains a formidable global health challenge. The current medication for AD gives …
remains a formidable global health challenge. The current medication for AD gives …
Current pharmacophore based approaches for the development of new anti-Alzheimer's agents
Amyloid beta peptide (Aβ) and hyperphosphorylated neuronal tau proteins accumulate in
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …
Lead optimization based design, synthesis, and pharmacological evaluation of quinazoline derivatives as multi-targeting agents for Alzheimer's disease treatment
The complexity and multifaceted nature of Alzheimer's disease (AD) have driven us to further
explore quinazoline scaffolds as multi-targeting agents for AD treatment. The lead …
explore quinazoline scaffolds as multi-targeting agents for AD treatment. The lead …
Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of …
Contemporary research evidence has corroborated a gradual loss of central cholinergic
neurons in Alzheimer's Disease (AD). This progressive deterioration leads to cognitive …
neurons in Alzheimer's Disease (AD). This progressive deterioration leads to cognitive …
Spectroscopic, DFT, In Silico, and Estimation of Biological Activity of 2, 4‐Dichloro‐6, 7‐Dimethoxyquinazoline as a Potential Anti‐Alzheimer's Disease Therapeutic …
K Asokan, S Sivaraman, K Nallasamy… - … Journal of Quantum …, 2025 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by
progressive cognitive and behavioral decline. In this study, 2, 4‐dichloro‐6, 7 …
progressive cognitive and behavioral decline. In this study, 2, 4‐dichloro‐6, 7 …
Combined Experimental and Computational Investigations of 4‐Amino‐2‐Chloro‐6, 7‐Dimethoxyquinazoline as Potential Anti‐Alzheimer Agent
K Asokan, K Nallasamy, S Sivaraman… - … Journal of Quantum …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative condition that leads to the deterioration of
brain cells, resulting in memory loss, thinking, and executive skills. In this work, 4‐amino‐2 …
brain cells, resulting in memory loss, thinking, and executive skills. In this work, 4‐amino‐2 …
Highly Efficient Catalysis of Pyridinium p‐Toluenesulfonate (PPTS): Two Facile One‐Pot Protocols for the Synthesis of 2, 3‐Disubstituted Quinazolinone Scaffolds
Y Chiranjeevi, LV Rao, A Raghunadh… - …, 2024 - Wiley Online Library
Two different one‐pot synthetic protocols have been developed for obtaining 2, 3‐
disubstituted quinazolin‐4 (3H)‐ones using pyridinium p‐toluenesulfonate (PPTS) as …
disubstituted quinazolin‐4 (3H)‐ones using pyridinium p‐toluenesulfonate (PPTS) as …