The fascinating patterns of collective motion created by autonomously driven particles have
fuelled active-matter research for over two decades. So far, theoretical active-matter …

As well as undergoing genetic evolution, cancer cells can alter their epigenetic state to
adapt and resist treatment. This non-genetic evolution is emerging as a major component of …

Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …

Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in
cancer, often observed independently of genetic heterogeneity, raising the central question …

Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …

Cancer cells within a tumour have heterogeneous phenotypes and exhibit dynamic
plasticity. How to evaluate such heterogeneity and its impact on outcome and drug response …

Glioblastoma progression in its early stages remains poorly understood. Here, we transfer
PDGFB and genetic barcodes in mouse brain to initiate gliomagenesis and enable direct …

Molecular differences between individual cells can lead to dramatic differences in cell fate,
such as death versus survival of cancer cells upon drug treatment. These originating …

Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …