Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Apoptosis is one of the main types of regulated cell death, a complex process that can be
triggered by external or internal stimuli, which activate the extrinsic or the intrinsic pathway …

Chromosomal rearrangements without gene fusions have been implicated in
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …

Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high …

Apoptosis is a form of programmed cell death that is critical for basic human development
and physiology. One of the more important surprises in cell biology in the last two decades is …

Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the
mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We …

Background Proteins of the BCL-2 family regulate clonal selection and survival of
lymphocytes, and are frequently overexpressed in lymphomas. Navitoclax is a targeted high …