Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel
their own growth and license tumor immune evasion. However, the relationships between …

The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies
strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In …

The corpus luteum (CL) is an important tissue of the female reproductive process which is
established through ovulation of the mature follicle. Pulsatile release of prostaglandin F2α …

Diabetes mellitus (DM) is a complex metabolic disease and it is also closely associated with
a reduction in fertility in male patients. The purpose of the present study was to investigate …

The zona fasciculata (zF) in the adrenal cortex contributes to multiple physiological actions
through glucocorticoid synthesis. The size, proliferation, and glucocorticoid synthesis …

High-density lipoprotein (HDL) is a heterogeneous mixture of blood-circulating
multimolecular particles containing many different proteins, lipids, and RNAs. Recent …

Triclosan (TCS) is an endocrine-disrupting chemical (EDC), which is used ubiquitously as
an antimicrobial ingredient in healthcare products and causes contamination in the …

In the mammalian testis, two distinct populations of Sertoli cells (SCs), the immature SCs
(ISCs) and adult SCs (ASCs), play significant roles in regulating the development and …

Cholesterol is the precursor of all steroids, but how cholesterol flux is controlled in
steroidogenic tissues is poorly understood. The cholesterol exporter ABCG1 is an essential …

Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes steroidogenic factor 1
(SF1), a key regulatory factor that determines gonadal development and coordinates …