Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
Metal complexes as DNA synthesis and/or repair inhibitors: anticancer and antimicrobial agents
MP Ngoepe, HS Clayton - Pharmaceutical Fronts, 2021 - thieme-connect.com
Medicinal inorganic chemistry involving the utilization of metal-based compounds as
therapeutics has become a field showing distinct promise. DNA and RNA are ideal drug …
therapeutics has become a field showing distinct promise. DNA and RNA are ideal drug …
Evaluating molecular docking software for small molecule binding to G-quadruplex DNA
J Dickerhoff, KR Warnecke, K Wang, N Deng… - International Journal of …, 2021 - mdpi.com
G-quadruplexes are four-stranded nucleic acid secondary structures of biological
significance and have emerged as an attractive drug target. The G4 formed in the MYC …
significance and have emerged as an attractive drug target. The G4 formed in the MYC …
“Dynamical Docking” of Cyclic Dinuclear Au (I) Bis-N-heterocyclic Complexes Facilitates Their Binding to G-Quadruplexes
With the aim to improve the design of metal complexes as stabilizers of noncanonical DNA
secondary structures, namely, G-quadruplexes (G4s), a series of cyclic dinuclear Au (I) N …
secondary structures, namely, G-quadruplexes (G4s), a series of cyclic dinuclear Au (I) N …
Synthesis and evaluation of the anticancer activity of [Pt (diimine)(N, N-dibutyl-N′-acylthiourea)]+ complexes
T Peega, RN Magwaza, L Harmse, IA Kotzé - Dalton Transactions, 2021 - pubs.rsc.org
Despite the concerted efforts to develop targeted cancer treatments, these therapies are
plagued by the rapid development of resistance and serious adverse drug reactions. Based …
plagued by the rapid development of resistance and serious adverse drug reactions. Based …
Development of DNA intercalative, HSA binder pyridine‐based novel Schiff base Cu (II), Ni (II) complexes with effective anticancer property: A combined experimental …
D Satapathi, M Das, K Rajak, S Laha… - Applied …, 2022 - Wiley Online Library
The two novel Cu (II) complexes [Cu (L)(CH3COO)] and [Cu (L)(N3)](1, 2) and one Ni (II)
complex [Ni (L)(N) 3](3) have been developed by using the ligand HL, obtained by the …
complex [Ni (L)(N) 3](3) have been developed by using the ligand HL, obtained by the …
DNA/Protein Binding and Apoptotic-Induced Anticancer Property of a First Time Reported Quercetin–Iron (III) Complex Having a Secondary Anionic Residue: A …
A new quercetin-based iron (III) cationic complex [Fe (Qr) Cl (H2O)(MeO)](complex 1) is
created in the current study by condensation of quercetin with ferric chloride in the presence …
created in the current study by condensation of quercetin with ferric chloride in the presence …
Synthesis and Evaluation of the Cytotoxic Activity of Water-Soluble Cationic Organometallic Complexes of the Type [Pt(η1-C2H4OMe)(L)(Phen)]+ (L = NH3, DMSO …
F De Castro, E Stefàno, D Migoni, GN Iaconisi… - Pharmaceutics, 2021 - mdpi.com
Starting from the [PtCl (η1-C2H4OMe)(phen)](phen= 1, 10-phenanthroline, 1) platinum (II)
precursor, we synthesized and characterized by multinuclear NMR new [Pt (η1 …
precursor, we synthesized and characterized by multinuclear NMR new [Pt (η1 …
Solvent-driven structural topologies in phenanthroline-based co-crystals of Zn (ii) involving fascinating infinite chair-like {[(bzH) 4 Cl 2] 2−} n assemblies and …
Two new co-crystals of Zn (II), viz.[Zn (phen) 3](bz)(Cl)· 8H2O (1) and [Zn (phen) 2
(bz)](Cl)(2bzH)(2)(phen= 1, 10-phenanthroline, bz= benzoate, bzH= benzoic acid), have …
(bz)](Cl)(2bzH)(2)(phen= 1, 10-phenanthroline, bz= benzoate, bzH= benzoic acid), have …
Fumarato and phthalato bridged dinuclear metal–organic Cu (ii) and Mn (ii) compounds involving infinite fumarate–water assemblies and unusual structure-guiding H …
Two new dinuclear coordination compounds viz.[Cu2 (μ-fum)(phen) 2 (H2O) 6](fum)· 6H2O
(1) and [Mn2 (μ-phth) 2 (phen) 4]· 2H2O (2)(phen= 1, 10-phenanthroline, fum= fumarate and …
(1) and [Mn2 (μ-phth) 2 (phen) 4]· 2H2O (2)(phen= 1, 10-phenanthroline, fum= fumarate and …