Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ
grows incredibly rapidly during this period, acting as a mastermind behind different fetal and …

Placental dysfunction underlies a spectrum of perinatal pathologies, including preeclampsia
and fetal growth restriction. Angiogenesis-related factors, including sFlt-1 (soluble fms-like …

Preeclampsia is a systemic syndrome that seems to originate from the placenta and is
associated with an imbalance between angiogenic factors in the maternal circulation. One of …

Background Preeclampsia presents a highly prevalent burden on pregnant women with an
estimated incidence of 2% to 5%. Preeclampsia increases the maternal risk of death 20-fold …

The maintenance of gestational well-being requires the proper development of both the
embryo and the placenta. Placental trophoblast cells are the major building blocks of the …

Objective This study aimed to:(1) identify all relevant studies reporting on the diagnostic
accuracy of maternal circulating placental growth factor) alone or as a ratio with soluble fms …

Fetal growth restriction (FGR) leading to low birth weight (LBW) is a major cause of neonatal
morbidity and mortality worldwide. Normal placental development involves a series of highly …

Introduction We aimed to systemically investigate the diagnostic capacity of soluble fms-like
tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio in fetal growth restriction (FGR) …

Importance Bile acids play essential roles in metabolic modulation. Excessive serum total
bile acid (sTBA) levels during pregnancy are associated with adverse perinatal outcomes; …