Challenges associated with curcumin therapy in Alzheimer disease

A Belkacemi, S Doggui, L Dao… - Expert reviews in …, 2011 - cambridge.org
Curcumin, the phytochemical agent in the spice turmeric, which gives Indian curry its yellow
colour, is also a traditional Indian medicine. It has been used for millennia as a wound …

Nanotechnology in the diagnostic and therapy for Alzheimer's disease

A Panghal, SJS Flora - Biochimica et Biophysica Acta (BBA)-General …, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by β-
amyloid plaque, intraneuronal tangles, significant neuronal loss and cognitive deficit …

Lipoprotein-based nanoparticles rescue the memory loss of mice with Alzheimer's disease by accelerating the clearance of amyloid-beta

Q Song, M Huang, L Yao, X Wang, X Gu, J Chen… - ACS …, 2014 - ACS Publications
Amyloid-beta (Aβ) accumulation in the brain is believed to play a central role in Alzheimer's
disease (AD) pathogenesis, and the common late-onset form of AD is characterized by an …

Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model

F Re, I Cambianica, C Zona, S Sesana… - … , Biology and Medicine, 2011 - Elsevier
A promising strategy to enhance blood-brain barrier penetration by drugs is the
functionalization of nanocarriers with uptake-facilitating ligands. We studied the cellular …

GM1-modified lipoprotein-like nanoparticle: Multifunctional nanoplatform for the combination therapy of Alzheimer's disease

M Huang, M Hu, Q Song, H Song, J Huang, X Gu… - ACS …, 2015 - ACS Publications
Alzheimer's disease (AD) exerts a heavy health burden for modern society and has a
complicated pathological background. The accumulation of extracellular β-amyloid (Aβ) is …

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer's Diseases

BF Far, M Safaei, A Pourmolaei… - ACS Applied Bio …, 2024 - ACS Publications
Alzheimer's disease (AD) is a neurological condition currently with 47 million people
suffering from it globally. AD might have many reasons such as genetic issues …

Evaluation of reconstituted high-density lipoprotein (rHDL) as a drug delivery platform–a detailed survey of rHDL particles ranging from biophysical properties to …

JB Simonsen - Nanomedicine: Nanotechnology, Biology and Medicine, 2016 - Elsevier
During the last decade, and with increasing intensity, the potential for using reconstituted
high-density lipoprotein (rHDL) particles to deliver hydrophobic drugs to impaired cells and …

Lecithin-based novel cationic nanocarriers (Leciplex) II: improving therapeutic efficacy of quercetin on oral administration

AA Date, MS Nagarsenker, S Patere… - Molecular …, 2011 - ACS Publications
The objective of the present investigation was to evaluate ability of the novel self-assembled
phospholipid-based cationic nanocarriers (LeciPlex) in improving the therapeutic efficacy of …

Learning from biology: synthetic lipoproteins for drug delivery

H Huang, W Cruz, J Chen… - Wiley Interdisciplinary …, 2015 - Wiley Online Library
Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical
agents (chemotherapeutics, siRNAs, photosensitizers, and imaging contrast agents) into …

Novel surface-engineered solid lipid nanoparticles of rosuvastatin calcium for low-density lipoprotein-receptor targeting: a Quality by Design-driven perspective

S Beg, S Jain, V Kushwah, GK Bhatti, PS Sandhu… - …, 2017 - Taylor & Francis
Aim: The present studies describe Quality by Design-oriented development and
characterization of surface-engineered solid lipid nanoparticles (SLNs) of rosuvastatin …