RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …

Genetic recombination in positive-strand RNA viruses is a significant evolutionary
mechanism that drives the creation of viral diversity by the formation of novel chimaeric …

The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts
and, potentially, undergo antigenic evolution depend on the ways genetic variation is …

RNA viruses rapidly adapt to selective conditions due to the high intrinsic mutation rates of
their RNA-dependent RNA polymerases (RdRps). Insertions and deletions (indels) in viral …

RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of
the parental wild-type virus. To examine their therapeutic potential, we created a DVG by …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not always
confined to the respiratory system, as it impacts people on a broad clinical spectrum from …

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-
associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and …

Viral infection outcomes are governed by the complex and dynamic interplay between the
infecting virus population and the host response. It is increasingly clear that both viral and …

RNA recombination is a major driving force in the evolution and genetic architecture shaping
of enteroviruses. In particular, intertypic recombination is implicated in the emergence of …

Huntington's disease (HD) is a neurodegenerative disorder caused by expansion of a CAG
trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine …