Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

The discovery, about forty years ago, of a-bungarotoxin, a three-finger a-neurotoxin from
Bungarus multicinctus venom, enabled the isolation of the nicotinic acetylcholine receptor …

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea
stagnalis is the established model for the ligand binding domains of the ligand-gated ion …

We have determined the crystal structure at 1.8 Å resolution of a complex of α-bungarotoxin
with a high affinity 13-residue peptide that is homologous to the binding region of the α …

The formation of a disulfide bond between adjacent cysteine residues is accompanied by
the formation of a tight turn of the protein backbone. In nearly 90% of the structures analyzed …

To identify high-affinity interactions between long-chain α-neurotoxins and nicotinic
receptors, we determined the crystal structure of the complex between α-btx (α …

To understand how snake neurotoxins interact with nicotinic acetylcholine receptors, we
have elaborated an experimentally based model of the α–cobratoxin–α7 receptor complex …

The nicotinic acetylcholine receptor (nAChR) carries two binding sites for snake venom
neurotoxins. α-Bungarotoxin from the Southeast Asian banded krait, Bungarus multicinctus …