Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

GM Lynn, C Sedlik, F Baharom, Y Zhu… - Nature …, 2020 - nature.com
Personalized cancer vaccines targeting patient-specific neoantigens are a promising cancer
treatment modality; however, neoantigen physicochemical variability can present challenges …

Immune checkpoint inhibition combined with targeted therapy using a novel virus-like drug conjugate induces complete responses in a murine model of local and …

RV Huis in 't Veld, S Ma, RC Kines… - Cancer Immunology …, 2023 - Springer
Metastases remain the leading cause of cancer-related death worldwide. Therefore,
improving the treatment efficacy against such tumors is essential to enhance patient survival …

[HTML][HTML] Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients

Y Dou, DTSL Jansen, A van Den Bosch, RA de Man… - Antiviral Research, 2020 - Elsevier
Synthetic long peptide (SLP) vaccination is a promising new treatment strategy for patients
with a chronic hepatitis B virus (HBV) infection. We have previously shown that a prototype …

Increased efficacy of NKT cell-adjuvanted peptide vaccines through chemical conjugation

CM Hayman, IF Hermans, GF Painter - Coupling and Decoupling of …, 2018 - Springer
Through vaccination infectious diseases such as smallpox, polio, measles, and tetanus have
either been eradicated or significantly restricted. However, there remain many diseases for …

[PDF][PDF] Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients

SI Buschow - scholarlypublications …
Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of
chronic HBV patients Page 1 Journal Pre-proof Design of TLR2-ligand-synthetic long peptide …