Circuit topology approach for the comparative analysis of intrinsically disordered proteins

B Scalvini, V Sheikhhassani… - Journal of Chemical …, 2023 - ACS Publications
Intrinsically disordered proteins (IDPs) lack a stable native conformation, making it
challenging to characterize their structure and dynamics. Key topological motifs with …

Continuum dynamics and statistical correction of compositional heterogeneity in multivalent IDP oligomers resolved by single-particle EM

B Mostofian, R McFarland, A Estelle, J Howe… - Journal of molecular …, 2022 - Elsevier
Multivalent intrinsically disordered protein (IDP) complexes are prevalent in biology and act
in regulation of diverse processes, including transcription, signaling events, and the …

Coevolution in Small Heat Shock Protein 1 (HSPB1) is Promoted by Interactions between the Alpha-Crystallin Domain and the Disordered Regions

V Racigh, MS Fornasari, L Rodriguez Sawicki… - bioRxiv, 2024 - biorxiv.org
Human HSPB1, a member of the small heat shock protein (sHSP) family, functions as an
ATP-independent molecular chaperone crucial for protein quality control and is implicated in …

Caracterización de la diversidad de la relación estructura-función en proteínas humanas

J Mac Donagh - 2021 - sedici.unlp.edu.ar
La mayoría de los estudios a gran escala para dilucidar reglas generales sobre el
comportamiento de las proteínas (estabilidad a sustituciones, diversidad conformacional …

Development and characterization of protein nanoformulations as alternative therapeutics to reduce antibiotic usage

JV Carratalá - 2021 - ddd.uab.cat
The emergence of bacterial drug resistance to conventional antibiotics is a global alarming
situation. This worrying scenario has forced the implementation of measures such us …