Sequential progression from chronic liver disease to fibrosis and to cirrhosis culminates in
neoplasia in hepatocellular carcinoma (HCC). The preneoplastic setting of the cirrhotic …

The Notch pathway represents a highly conserved signaling network with essential roles in
regulation of key cellular processes and functions, many of which are critical for …

Members of the transforming growth factor-β (TGF-β) family are potent regulatory cytokines
that affect multiple cell types of the immune system mediating pro-inflammatory or anti …

COVID-19 is associated with a large number of cardiovascular sequelae, including
dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one …

Hepatocellular carcinoma (HCC) is the leading cause of cancer death, and hepatitis B virus
(HBV) infection is one of the commonest causes in Asian countries. India has the second …

Liver fibrosis is characterized by an increased and altered deposition of extracellular matrix
(ECM) proteins that make up excessive tissue scarring and promote chronic liver injury …

Interactions between liver cells are closely regulated by Notch signaling. Notch signaling
has been reported clinically related to bile duct hypogenesis in Alagille syndrome, which is …

Hepatitis B virus (HBV) which includes, fulminant, acute, chronic, asymptomatic, and occult
HBV infection is the most prevalent virus that leads to human liver diseases. Chronic …

MicroRNAs (miRNAs) are short non-coding RNAs involved in biological and pathological
processes of every cell type, including liver cells. Transcribed from specific genes, miRNA …

The Notch signaling pathway has been reported to play crucial roles in inhibiting hepatocyte
differentiation and allowing formation of intrahepatic bile ducts. However, little is known …