Duchenne muscular dystrophy (DMD) is caused by frameshift mutations in the DMD gene
that prevent the body-wide translation of its protein product, dystrophin. Besides a severe …

Duchenne muscular dystrophy (DMD) and the allelic disorder Becker muscular dystrophy
(BMD) are common X-linked recessive neuromuscular disorders that are associated with a …

Dystrophin Dp71 is expressed in all tissues, with the exception of skeletal muscle, and is the
main Duchenne muscular dystrophy (DMD) gene product in brain. As full-length dystrophin …

Dp71 is the major product of the Duchenne muscular dystrophy gene in the brain. In order to
study the function of Dp71 in the nervous system we examined the expression of Dp71 …

The subcellular distribution of Dp71 isoforms alternatively spliced for exon 71 and/or 78 was
examined. The cDNA sequence of each variant was fused to the C-terminus of the green …

To determine the role of Dp71 in neuronal cells, we generated PC12 cell lines in which
Dp71 protein levels were controlled by stable transfection with either antisense or sense …

Dystrophin Dp71 is the major product of the Duchenne muscular dystrophy (DMD) gene in
the brain, and its loss in DMD patients and mouse models leads to cognitive impairments …

We have adopted the PC12 cell line as in vitro cell model for studying Dp71 function in
neuronal cells. These cells express a cytoplasmic (Dp71f) and a nuclear (Dp71d) isoform of …

Dystrophin Dp71 is the main product of the Duchenne muscular dystrophy gene in the brain;
however, its function is unknown. To study the role of Dp71 in neuronal cells, we previously …

Previously, we reported that PC12 cells with decreased Dp71 expression (antisense-Dp71
cells) display deficient nerve-growth-factor-induced neurite outgrowth. In this study, we show …