Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
It is generally thought that many drug molecules are transported across biological
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …
Disease detection and management via single nanopore-based sensors
As nanometer-scale portals in biological membranes, protein ionic channels act as
gatekeepers, controlling the traffic of ions and macromolecules into and out of cells …
gatekeepers, controlling the traffic of ions and macromolecules into and out of cells …
Permeation of protons, potassium ions, and small polar molecules through phospholipid bilayers as a function of membrane thickness
S Paula, AG Volkov, AN Van Hoek, TH Haines… - Biophysical journal, 1996 - cell.com
Two mechanisms have been proposed to account for solute permeation of lipid bilayers.
Partitioning into the hydrophobic phase of the bilayer, followed by diffusion, is accepted by …
Partitioning into the hydrophobic phase of the bilayer, followed by diffusion, is accepted by …
Permeability of lipid bilayers to water and ionic solutes
DW Deamer, J Bramhall - Chemistry and physics of lipids, 1986 - Elsevier
The lipid bilayer moiety of biological membranes is considered to be the primary barrier to
free diffusion of water and solutes. This conclusion arises from observations of lipid bilayer …
free diffusion of water and solutes. This conclusion arises from observations of lipid bilayer …
The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone)
R Benz, S McLaughlin - Biophysical journal, 1983 - cell.com
We propose a simple model that accounts for the ability of the weak acid FCCP
(Carbonylcyanide-p-trifluoromethoxyphenylhydrazone) to both transport protons across …
(Carbonylcyanide-p-trifluoromethoxyphenylhydrazone) to both transport protons across …
Nanoscale measurement of the dielectric constant of supported lipid bilayers in aqueous solutions with electrostatic force microscopy
We present what is, to our knowledge, the first experimental demonstration of dielectric
constant measurement and quantification of supported lipid bilayers in electrolyte solutions …
constant measurement and quantification of supported lipid bilayers in electrolyte solutions …
Self-assembled phospholipid/alkanethiol biomimetic bilayers on gold
AL Plant - Langmuir, 1993 - ACS Publications
Alkanethiols can act as hydrophobic monolayer substrates for the formation of phospholipid-
containing bilayers. Phospholipid vesicles were allowed to fuse to alkanethiol monolayers …
containing bilayers. Phospholipid vesicles were allowed to fuse to alkanethiol monolayers …
Soluble amyloid β-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity
It is well established that Alzheimer's amyloid β-peptides reduce the membrane barrier to ion
transport. The prevailing model ascribes the resulting interference with ion homeostasis to …
transport. The prevailing model ascribes the resulting interference with ion homeostasis to …
Designing artificial cells to harness the biological ion concentration gradient
Cell membranes contain numerous nanoscale conductors in the form of ion channels and
ion pumps,,, that work together to form ion concentration gradients across the membrane to …
ion pumps,,, that work together to form ion concentration gradients across the membrane to …
Drude polarizable force field for molecular dynamics simulations of saturated and unsaturated zwitterionic lipids
Additive force fields are designed to account for induced electronic polarization in a mean-
field average way, using effective empirical fixed charges. The limitation of this …
field average way, using effective empirical fixed charges. The limitation of this …