Glycolipids are ubiquitous and biologically important molecules and are involved in diverse
biological functions and exhibit biosurfactant applications due to their surface-active and …

Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …

The heterotrimeric Sec61 complex is a major site for the biogenesis of transmembrane
proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic …

Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with
single-digit nanomolar potency. However, its biological and pharmacological properties …

A one‐pot O‐alkylation mediated macrocyclization approach has been used for the
synthesis of carbohydrate‐based macrocyclic azobenzene. The synthesized macrocycle can …

Carbohydrate‐based drug discovery has gained more and more attention during the last few
decades. Resin glycoside is a kind of novel and complex glycolipids mainly distributed in …

The first total synthesis of the purported structure of branched resin glycosides merremoside
G and H2 is accomplished. A signature step is represented by the sequential transition …

Amphiphilicity is one of the desirable features in the process of drug development which
improves the biological as well as the pharmacokinetics profile of bioactive molecule …

Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and
evaluated. Improved cytotoxicity (IC50: from 1.8 nM) and in vitro protein translocation …