[HTML][HTML] A critical review of palladium organometallic anticancer agents

T Scattolin, VA Voloshkin, F Visentin… - Cell Reports Physical …, 2021 - cell.com
With the aim of overcoming the well-known limitations of platinum-based antineoplastic
drugs, recent efforts have focused on the development of new anticancer agents containing …

Bioactivity and development of small non-platinum metal-based chemotherapeutics

MG Ferraro, M Piccolo, G Misso, R Santamaria, C Irace - Pharmaceutics, 2022 - mdpi.com
Countless expectations converge in the multidisciplinary endeavour for the search and
development of effective and safe drugs in fighting cancer. Although they still embody a …

Advances in the Synthesis and Applications of N-Heterocyclic Carbene Metal Complexes with a Focus on the Weak Base Route

T Scattolin, AA Logvinov, NV Tzouras, CSJ Cazin… - …, 2023 - ACS Publications
N-heterocyclic carbene (NHC) ligands have evolved from being simple lab curiosities to
tertiary phosphine mimics to finally take center stage as unique supporting ligands in …

N-Heterocyclic carbene complexes enabling the α-arylation of carbonyl compounds

S Ostrowska, T Scattolin, SP Nolan - Chemical Communications, 2021 - pubs.rsc.org
The considerable importance of α-arylated carbonyl compounds, which are widely used as
final products or as key intermediates in the pharmaceutical industry, has prompted …

Multistimuli-responsive fluorescent organometallic assemblies based on mesoionic carbene-decorated tetraphenylethene ligands and their applications in cell …

Y Li, T Yang, N Li, S Bai, X Li, LL Ma, K Wang… - CCS …, 2022 - chinesechemsoc.org
The controllable construction of light-emitting organometallic supramolecular materials
integrating stimulus responses and biological applications is still a major challenge today. In …

Strategies for the construction of supramolecular assemblies from poly-NHC ligand precursors

Y Li, JG Yu, LL Ma, M Li, YY An, YF Han - Science China Chemistry, 2021 - Springer
The field of supramolecular assemblies has developed rapidly in the last few decades,
thanks in a large part to their diverse applications. These assemblies have been mostly …

Early warnings by liver organoids on short-and long-chain PFAS toxicity

S Palazzolo, I Caligiuri, AA Sfriso, M Mauceri… - Toxics, 2022 - mdpi.com
Short-chain per-fluoroalkyl substances (PFAS) have replaced long-chains in many
applications, however the toxicity and its mode of action and interactions due to the large …

Continuous flow synthesis of metal–NHC complexes

A Simoens, T Scattolin, T Cauwenbergh… - … A European Journal, 2021 - Wiley Online Library
The use of weak bases and mild conditions is currently the most sustainable and attractive
synthetic approach for the preparation of late‐transition metal complexes, some of which are …

Indenyl and Allyl Palladate Complexes Bearing N‐Heterocyclic Carbene Ligands: an Easily Accessible Class of New Anticancer Drug Candidates

T Scattolin, I Pessotto, E Cavarzerani… - European Journal of …, 2022 - Wiley Online Library
The mechanochemical syntheses of allyl and indenyl palladate complexes are reported. All
compounds were obtained in quantitative yields and microanalytically pure without the need …

Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy

E Bortolamiol, F Visentin, T Scattolin - Applied Sciences, 2023 - mdpi.com
The introduction of biologically relevant organic moieties in the coordination sphere of
transition metal complexes has recently become a well-established strategy to increase the …