Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to
treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively …

Human pluripotent stem cells (PSCs) are a promising source of cells for applications in
regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal …

Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a
powerful tool to study disease mechanisms and to elucidate unexplored aspects of this …

Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide
dopaminergic innervation to the striatum. This discovery led to the successful instigation of …

Autologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …