Mechanisms of otoconia and otolith development

YW Lundberg, Y Xu, KD Thiessen… - Developmental …, 2015 - Wiley Online Library
Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …

Zebrafish models of human eye and inner ear diseases

B Blanco-Sánchez, A Clément, JB Phillips… - Methods in cell …, 2017 - Elsevier
Eye and inner ear diseases are the most common sensory impairments that greatly impact
quality of life. Zebrafish have been intensively employed to understand the fundamental …

Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos

M Sundvik, HJ Nieminen, A Salmi, P Panula… - Scientific reports, 2015 - nature.com
Acoustic levitation provides potential to characterize and manipulate material such as solid
particles and fluid in a wall-less environment. While attempts to levitate small animals have …

Autosomal-recessive hearing impairment due to rare missense variants within S1PR2

RLP Santos-Cortez, R Faridi, AU Rehman… - The American Journal of …, 2016 - cell.com
The sphingosine-1-phosphate receptors (S1PRs) are a well-studied class of transmembrane
G protein-coupled sphingolipid receptors that mediate multiple cellular processes. However …

[HTML][HTML] Small fish, big prospects: using zebrafish to unravel the mechanisms of hereditary hearing loss

B Vona, J Doll, MAH Hofrichter, T Haaf, GK Varshney - Hearing research, 2020 - Elsevier
Over the past decade, advancements in high-throughput sequencing have greatly enhanced
our knowledge of the mutational signatures responsible for hereditary hearing loss. In its …

Diverse functions of lipids and lipid metabolism in development

Y Yao, L Ding, X Huang - Small Methods, 2020 - Wiley Online Library
Developmental processes result from interactions between the external environment and
internal factors. Recent discoveries have demonstrated the essential roles of lipid metabolic …

Water waves to sound waves: using zebrafish to explore hair cell biology

SB Pickett, DW Raible - Journal of the Association for Research in …, 2019 - Springer
Although perhaps best known for their use in developmental studies, over the last couple of
decades, zebrafish have become increasingly popular model organisms for investigating …

[HTML][HTML] Sphingosine 1-phosphate-mediated activation of ezrin-radixin-moesin proteins contributes to cytoskeletal remodeling and changes of membrane properties in …

F Cencetti, C Bernacchioni, M Bruno, R Squecco… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Hearing loss is among the most prevalent sensory impairments in humans. Cochlear
implantable devices represent the current therapies for hearing loss but have various …

[HTML][HTML] Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts

M Bruno, IM Rizzo, R Romero-Guevara… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Hearing loss affects millions of people in the world. In mammals the auditory system
comprises diverse cell types which are terminally differentiated and with no regenerative …

Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?

R Romero-Guevara, F Cencetti, C Donati… - Frontiers in aging …, 2015 - frontiersin.org
Hearing loss is one of the most prevalent conditions around the world, in particular among
people over 60 years old. Thus, an increase of this affection is predicted as result of the …